It is topically applied to treat melisma, freckles and senile lentigines. Hydroquinone, usp hydroquinone, usp sds preparation date 10172016. Hydroquinone safety data sheet according to federal register vol. It also finds use in topical skin creams and lotions for. It may be found in concentrations up to 15% or more but a doctors prescription is required by the fda united states for. Hydroquinone did not cause birth defects when given orally to pregnant rats at doses up to 300 mgkgday. Responses were not consistent across route of exposure, species or sex. Hydroquinone for cosmetic use is chemically synthesized. Extrasynthese is a leading chemicals company that provides customers with highquality hydroquinone standard reference material.
Acgih threshold limit values 01 2010 pel 2 mgm3 us. Black and white bleaching cream with hydroquinone walgreens. Osha table z1 limits for air contaminants 29 cfr 1910. Show this safety data sheet to the doctor in attendance. It is used in photographic, chemical and cosmetic industries. Pure hydroquinone does not readily form a vapor at room temperature. Exposure controlspersonal protection components with workplace control parameters components casno. Hydroquinone decreases the formation of melanin in the skin. Hydroquinone also may be an important factor in the defense mechanis some insects, most notably the bombardier beetle hsdb, 2005 hydroquinone may be released into the environment during its produ. Safety data sheet according to federal register vol.
Buy hydroquinone cas 123319, a quinone small molecule with efficacy as a topical preparation, from santa cruz. The frequency of fetal death was increase among rats fed 2500 mgkg of hydroquinone. Hydroquinone reference material extrasynthese, hydroquinone. Chlorophacinone is a diarylmethane and a betatriketone. The user must determine suitability of this information for his application. No warranty, express or implied, is made and qorpak assumes no liability resulting from the use of this msds. In the presence of air and moisture, hydroquinone dust may react to form irritating quinone which forms a vapor at room temperature. Hydroquinone, also known as benzene1, 4diol, is an aromatic organic compound which is a type of phenol, having the chemical formula c6h4oh2. Material safety data sheet section 1 hydroquinone 1 chemical product and company identification msds name. Material safety data sheet eastman chemical company. Amended safety assessment of hydroquinone as used in. The dust my cause irritation of the nose, throat and upper respiratory tract. Members of the ectonox family, such as cnox, or enox1, are involved in plasma membrane transport pathways.
Material safety data sheet west liberty university. Commercially available as oil concentrate and as dust concentrate. Hydroquinone msds 822333 milliporesigma emd millipore. Value control parameters update basis hydroquinone 123319 twa 1 mgm3 20080101 usa. Achieve a more even tone with hydroquinonefree skin lighteners and brighteners. Qualitative and quantitative estimation of hydroquinone in. May cause severe irritation of the digestive tract. Melasma is blotchy brown discoloration of the face caused by pregnancy, birth control, normal female hormones and is exacerbated by the sun. Sewage sludge activated to phenol was found to oxidize hydroquinone 3,4. It works by inhibiting an enzyme reaction in skin cells.
Headaches, dizziness, nausea, and cyanosis may result from overexposure to. Material safety data sheet hydroquinone msds section 1. A schimadzu lc9 was used with uv detector set at 295 nm having ods column 25 cm. First aid measures description of firstaid measures general advice.
You also can through below form to request documents for moa,ros,1hnmr. Commission regulation eu no 2015830 of 28 may 2015. Sewage sludge activated to phenol was found to oxidize hydroquinone3,4. If medical advice is needed, have product container or label. Hydroquinone is an active allergen so repeated and prolonged exposure may cause skin sensitization. Amended safety assessment of hydroquinone as used in cosmetics. Suspected of causing cancer very toxic to aquatic life precautionary statements. Material safety data sheet hydroquinone 6 information in this msds is from available published sources and is believed to be accurate. This staining is temporary and can typically be removed with soap and water washing, but its best to avoid benzoyl peroxidebased acne treatments and oxygeninfusing skin care treatments, which. Pure culture oxidation of hydroquinone produced 1,4benzoquinone, 2hydroxy1,4benzoquinone and betaketoadipic acid5. Identification of the substancemixture and of the companyundertaking 1. Substituted derivatives of this parent compound are also referred to as hydroquinones. Despite the controversy, its abundantly clear is that hydroquinone is a wellresearched ingredient, incredibly effective for its intended purpose, and that no other skin lightening ingredient compares to its effectiveness.
Shop lovelyskin for exclusive offers, free shipping and samples. Over the past several years, hydroquinone has become a controversial skincare ingredient for topical use. Hydroquinone, also known as benzene1,4diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula c 6 h 4 oh 2. To go further in meeting our customers needs, certificates of analysis coa, material safety data sheets msds, and technical specifications are available for all our products online or upon request. Extinguishing media protective equipment and wear selfcontained breathing apparatus and protective clothing to prevent contact with skin and eyes. Hydroquinone according to regulation ec no 19072006, annex ii, as amended. Hydroquinone topical is used to lighten areas of darkened skin such as freckles, age spots, chloasma, and melasma. Skin darkening is called epidermal hyperpigmentation and is caused by the deposit of too much melanin normal skin pigment in the skin. Chemical properties of hydroquinone cas 123319 download as pdf file download as excel file download as 2d mole file predict properties. Rats and mice were given hydroquinone by stomach tube or at high concentrations in the diet. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. The guide is intended to supplement training, material safety data sheets msdss, safety.
Hydroquinone is linked to exogenous ochronosis, dermatitis and skin. Chemical product and company identification product name. Registrationlogin is required to view the sheets which appear to be all in pdf format. The international agency for research on cancer iarc has classified hydroquinone in group 3, i. Clinical director, innovative skincare topical hydroquinone is used frequently throughout the world as a skin bleaching agent. Material safety data sheet hydroquinone 2 ingestion. Hydroquinone is a phenolic compound, which is naturally found in coffee, tea and wine. First aid eye contact immediately flush with large amounts of water for at least 30 minutes, lifting upper and lower lids. Hydroquinone is on the right to know hazardous substance list because it is cited by osha, acgih, dot, niosh, dep, iarc, nfpa and epa. Hydroquinone is commonly used as a biomarker for benzene exposure. Hydroquinone patient instructions what is hyperpigmentation. All products should be stored at a dry and ventilated location away from fire and other dangerous goods, and should avoid direct sunlight. The presence of hydroquinone in normal individuals stems mainly from direct dietary. Page 2 of 14 safety data sheet section 2 hazards identification continued label elements danger hazard statements harmful if swallowed causes skin irritation causes serious eye damage.
Achieve a more even tone with hydroquinone free skin lighteners and brighteners. It is formed in large quantities by chemical reduction of benzoquinone. Hydroquinone is a watersoluble reducing agent making it an excellent polymerization inhibitor for acrylates. Hydroquinone can be found on the following state righttoknow lists. Melanin is the pigment in skin that gives it a brown color. Hydroquinone has been detected in cigarette smoke mainstream and. All products should be stored at a dry and ventilated location away from fire and. Sigmaaldrich material safety data sheet date printed. Get medical adviceattention p310 immediately call a poison centerdoctor p330 if swallowed, rinse mouth. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. The mobile phase was a mixture of water and ethanol 45.
Hydroquinone is a watersoluble reducing agent making it an excellent polymerization inhibitor for acrylates it also finds use in topical skin creams and lotions for reducing the signs of age. Product identifier product name hydroquinone product number fh01233 synonyms. May cause dizziness, nausea, sense of suffocation, increased respiratory rate, vomiting, pallor, muscle twitching, cyanosis bluish discoloration of skin due to deficient oxygenation of the blood, delirium. May cause irritation of the nose and respiratory tract. The rate of malformations was not significantly increased among the offspring of rabbits administered doses up to 150 mgkgday during pregnancy. Despite the controversy, its abundantly clear is that hydroquinone is a wellresearched ingredient, incredibly effective for its intended purpose, and that no other.
This compound is a generalpurpose inhibitor, stabilizer, antioxidant, and intermediate. Hydroquinone cas 123319 scbt santa cruz biotechnology. Ac12090, ac120910020, ac120910050, ac120915000, ac219930000, ac219930050 ac219930050, ac219930500, h329500 synonyms. These enzymes exhibit both a hydroquinone nadh oxidase activity and a protein disulfidethiol interchange activity in series, with each activity cycling every 22 to 26 minutes scarlett et al. Date hs code description origin country port of discharge unit quantity value inr per unit inr nov 22 2016.
59 1335 212 608 1541 920 1235 1294 1232 1417 232 224 415 113 597 651 190 244 1032 1155 1398 669 791 152 1082 176 162 128 405 1450 812 954 965